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Agave testing halted due to health dangers #fb

October 3, 2010

More information on Agave and Blood Sugar Issues…



The Glycemic Research Institute® announced that they have legally “De-Listed” and placed a ban on Agave for use in Foods, Beverages, Chocolate, and any other products, due to results of 5 years of Human In Vivo Clinical Trials on Agave.Manufacturers who produce and use Agave in products are now warned that they can be held legally liable for negative health incidents related to ingestion of Agave.
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Agave Clinical Trials Halted Due to
Severe Side Effects in Diabetics

The Glycemic Research Institute® announced that they have halted and banned all future clinical trials of Agave and are issuing warnings to manufacturers and the public about the dangers related to Agave.The Medical Advisory Board of the Glycemic Research Institute® (GRI) made the decision to halt all future clinical trials involving Agave as a result of the latest round of GRI Human In Vivo Clinical Trials, in which the diabetic subjects experienced severe and dangerous side effects related to the oral ingestion of the sweetener Agave.

This announcement came as a surprise to the scientific community, and has generated hundreds of inquiries involving the safety of ingesting Agave.

Physicians and diabetes health educators are now being advised to caution their diabetic patients, both adults and children, about the use of Agave.

This also applies to persons with Metabolic Syndrome, Insulin Resistance, and Pre-Diabetes. The medical community believes that up to 70% of the American public has some form of Insulin Resistance, due to the rise in obesity and weight gain.

The ban on Agave includes “The use of Agave as a sweetener and/or syrup, as found in foods, beverages, Nutraceuticals, chocolate, and any other consumable product.”


Results of the Human In Vivo Clinical Trials involving Agave resulted in alarming effects evidenced in the diabetic trial subjects.

According to the researchers, the side effects seen in the diabetic population are related to dosage. Very small amounts of orally ingested Agave did not instigate immediate side effects in diabetics, while larger doses caused severe side effects.

The Glycemic Research Institute® is legally bound to alert the appropriate government and health authorities, as well as the public, of any clinical trial results that pose a health problem to the public-at-large.

The Wall Street Journal interviewed researchers at the Glycemic Research Institute® in 2009 (article available at Wall Street Journal online), when results of the Agave trial were made public.

As of 2009, manufacturers and marketers of products containing Agave can now be held legally responsible for any negative medical issues resulting from ingestion of Agave. The legal community has contacted the Glycemic Research Institute® for verification and documentation that Agave does elicit negative results in person with blood-sugar and other related metabolic issues, and are prepared to take these issues to court.


The Glycemic Research Institute® Agave trials, as well as other independent data and research, demonstrate that diabetics respond differently to oral ingestion of Agave than non-diabetics and persons with normal glycemic responses.

The biochemical reason is that all cells in the body, including liver, muscle, and brain cells, are dependent on glucose as fuel. Glucose is not capable of diffusing from the bloodstream into the cells, and requires specialized proteins (not dietary protein) to transport it across cellular membranes.

Insulin is the catalyst for the cell-transporters that deliver glucose into heart, muscle, and fat cells. Excess insulin causes adipose tissue fat storage via Lipoprotein Lipase (LPL), so foods and beverages that stimulate insulin cause weight gain and obesity. This explains why Type 1 diabetics (lack of insulin) are thin and Type 2 diabetics (excess insulin) are almost always overweight or obese.

The brain, however, works on a different fuel-basis. Glucose can get into the brain to act as fuel (glucose-transport), while insulin cannot, and fat-storage in the brain is not an option. The Blood-Brain-Barrier (BBB) is the watch-dog in the brain that is responsible for regulating the amount of sugar/glucose going to cells inside the brain. The BBB only allows very specific agents to enter the brain by crossing the Blood-Brain-Barrier (BBB).

In diabetics, muscle cells cannot obtain sufficient energy to function normally, because the diabetic’s ability to properly produce and/or utilize insulin is impaired. Diabetic serum levels of glucose are consistently over-elevated, yet muscle cells are stressed and starving.

Diabetics using insulin-treatments (medication) often experience excess insulin stimulation and uptake, resulting in insufficient levels of glucose in the bloodstream.

Imbalances in blood glucose and insulin levels are the standard trademark of a diabetic patient. In type 2 diabetes (by far the most common form of diabetes), high blood glucose levels cause weight gain and obesity, which exacerbates insulin resistance, risk of cardiovascular disease, and shortened life span. High insulin levels further trigger weight gain and obesity, as well as a myriad of health problems.

These imbalances are problematic in the diabetic, as every food, meal, snack, beverage, or orally ingested agent, causes a glycemic reaction, ranging from mild to severe.

High glycemic foods, beverages, and sweeteners stimulate high levels of serum glucose, which makes diabetics susceptible to neurological and physical problems, including stroke and memory loss.

In a hyper-insulin state, which is triggered by ingesting foods, beverages, and sweeteners that over-stimulate insulin, muscle cells take up all of the available glucose, thus depriving the brain of sufficient fuel.

This causes severe Metabolic Low Blood Sugar, resulting in wooziness, poor motor and thinking function, extreme lethargy, and in many cases, lack of consciousness (fainting/passing out).

Even foods and beverages that claim No-Calories, No-Carbs, cause a reaction in the diabetic and pre-diabetic.

This is because the human brain has to contend with high and low levels of glucose in the blood stream. Severe imbalances, including very low levels of glucose, and reactive hypoglycemia, can place diabetics in a precarious physical condition, in which there is literally a “brain shut-down.”

This type of metabolic cascade causes severe diabetic reactions, including passing out – even behind the wheel of a car while driving, and explains why oral ingestion of Agave induces potentially dangerous metabolic states in diabetics.

IN SUMMARY: Diabetics and persons with any insulin-related disorder, including Pre-Diabetes and Insulin Resistance, are urged to use extreme caution as related to oral ingestion of Agave and Agave sweeteners and syrups.


Medical and/or media-related questions may be addressed to the Glycemic Research Institute, Human in Vivo Clinical Trials Facility at (727) 894-6900 or via e mail from the Official Glycemic Research Institute® website at

6 Comments leave one →
  1. organicgal permalink
    October 19, 2010 10:27 pm

    Pretty hysterical that a Google ad for HFCS and the agribusiness shill site Sweet Surprise appears at the bottom of this article!

  2. thetruethplease permalink
    November 20, 2010 8:19 pm

    Once I read the article from the GRI I still am convinced that these people, not this site, but the cited source, are nothing more than paid off by Big Food makers to stop people from having a natural choice for a sugar substitute. The FDA is nothing more than a henchman for Big Food Corps that have only one thing in mind, to make us sick, then treat us with meds that create secondary side effects for them to treat. I read the reasons it was “banned” and it clearly states one as being given in high doses. You can NOT have a high dose of agave, it will raise your sugar level. It’s meant to be used in moderation, but that’s not mentioned. It also has on there that the ingredients by some companies had “other” ingredients included not listed. I stand by my first impression of crap. One more thing to mention. My sister is diabetic and has been using agave in moderation with ZERO effects. She was told about this by her doctor who has other patients with ZERO side effects. To me, it was like they gave these poor people a shot of nothing more than pure sugar water and waited for the reaction to just get it removed. In other words, they fudge the testing and threw the results. Read it at their own site in their own words. Again giving these people very high doses – causing severe reactions. Then they say anyone using agave in product manufactoring could be sued? Yep bought off.

  3. January 18, 2011 10:51 am

    I’m so glad you posted this. I too jumped on the agave craze only to find I would feel my blood sugar spike, and feel terrible afterwards. I couldn’t understand it as it was so prevalent in raw and healthy foods. But I trust my body so I stopped. I switched to coconut sugar and find I feel totally fine after eating it. Besides, I like to put things in my body that have nutrients, including sweeteners – like black strap molasses and coconut sugar. Agave has no nutrients and reacts in my body the same as fructose.

    Great post. Thanks.

  4. Christina Fitchett permalink
    September 16, 2011 9:29 am

    Thank you for this article. I too tried the asweetener and would feel pretty bad after eating it. I thought it was just me and still used agave. I continued with the other symptoms. I got light headed and dizzy often. I quit the agave because I ran out and never bought it again and the symptoms have stopped. Maybe it was the agave!

  5. Brian permalink
    June 18, 2012 9:42 am

    You may want to know why this article was removed from the GRI website… Lawsuit discovered the “reaction” to agave NEVER occurred as they described it. They gave three people 4 times as much as directed on the label (4 times as much as their previous test in 2005 resulting in a Diabetic Friendly Seal of Approval) and one person out of three reported “nausea” and stopped the test. No rushing to the hospital, no diabetic coma, no nothing. They gave her some water and a protein bar and her symptoms resolved.

    Interestingly enough… the owner of GRI created her own sweetener after the 2005 testing of agave and before the false “private” test results were misstated on their site in 2009. You tell me why those false statements were made??? Conflict of interest maybe?


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